Leucovorin

Overview

Leucovorin is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL1679).

API suppliers (3)

Suppliers of Leucovorin backed by a verifiable FDA Type II Drug Master File. Source: FDA quarterly DMF list.

• MONSANTO CO
• ORION CORP FARMOS CHEMICAL PLANT
• GMT FINE CHEMCALS SA

Patent & exclusivity (US)

Per the FDA Orange Book (48 approved US products), the latest listed US patent on Leucovorin expires 23 Dec 2044. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

(2S)-2-[[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid

Canonical SMILES

C1C(N(C2=C(N1)NC(=NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O

InChIKey

VVIAGPKUTFNRDU-ABLWVSNPSA-N