Itraconazole

Overview

Itraconazole is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL64391).

API suppliers (22)

Suppliers of Itraconazole backed by a verifiable FDA Type II Drug Master File. Source: FDA quarterly DMF list.

• QUIMICA SINTETICA SASpain1 active DMF
• W R GRACE AND CO -CONN1 active DMF
• Neuland Laboratories LimitedIndia1 active DMF
• MATRIX PHARMACORP PRIVATE LTD1 active DMF
• ALIVUS LIFE SCIENCES LTD1 active DMF
• QUIMICA SINTETICA SASpain1 active DMF
• Neuland Laboratories LimitedIndia1 active DMF
• JBC Pharmaceuticals Ltd.United Kingdom1 active DMF
• COHANCE LIFESCIENCES LTD1 active DMF
• Neuland Laboratories LimitedIndia1 active DMF
• MATRIX PHARMACORP PRIVATE LTD1 active DMF
• ALIVUS LIFE SCIENCES LTD1 active DMF
• Neuland Laboratories LimitedIndia1 active DMF
• QUIMICA SINTETICA SASpain1 active DMF
• MATRIX PHARMACORP PRIVATE LTD1 active DMF
• ALIVUS LIFE SCIENCES LTD1 active DMF
• JBC Pharmaceuticals Ltd.United Kingdom1 active DMF
• QUIMICA FINA FARMEX SA DE CV
• Hetero Drugs LimitedIndia
• PIRAMAL HEALTHCARE LTD
• APOTECNIA SA
• SOCIETA ITALIANA MEDICINALI SCANDICCI

Patent & exclusivity (US)

Per the FDA Orange Book (11 approved US products), the latest listed US patent on Itraconazole expires 20 Jun 2033. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one

Canonical SMILES

CCC(C)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OCC5COC(O5)(CN6C=NC=N6)C7=C(C=C(C=C7)Cl)Cl

InChIKey

VHVPQPYKVGDNFY-UHFFFAOYSA-N