Isavuconazonium

Overview

Isavuconazonium is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL1183349).

API suppliers (2)

Suppliers of Isavuconazonium evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

• METROCHEM API PRIVATE LTDIndia1 active DMF
• Porton Pharma Solutions Ltd.China1 active DMF

Patent & exclusivity (US)

Per the FDA Orange Book (3 approved US products), the latest listed US patent on Isavuconazonium expires 14 Mar 2028 and exclusivity 8 Jun 2031. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

[2-[1-[1-[(2R,3R)-3-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-2-(2,5-difluorophenyl)-2-hydroxybutyl]-1,2,4-triazol-4-ium-4-yl]ethoxycarbonyl-methylamino]-3-pyridinyl]methyl 2-(methylamino)acetate

Canonical SMILES

C[C@@H](C1=NC(=CS1)C2=CC=C(C=C2)C#N)[C@](CN3C=[N+](C=N3)C(C)OC(=O)N(C)C4=C(C=CC=N4)COC(=O)CNC)(C5=C(C=CC(=C5)F)F)O

InChIKey

RSWOJTICKMKTER-QXLBVTBOSA-N