Irinotecan

Overview

Irinotecan is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL481).

API suppliers (29)

Suppliers of Irinotecan backed by a verifiable FDA Type II Drug Master File. Source: FDA quarterly DMF list.

• Sun Pharmaceutical Industries LimitedIndia2 active DMF
• Emcure Pharmaceuticals LimitedIndia1 active DMF
• PLIVA-LACHEMA AS1 active DMF
• JIANGSU HENGRUI PHARMACEUTICALS CO LTDChina1 active DMF
• PLIVA-LACHEMA AS1 active DMF
• JIANGSU HENGRUI PHARMACEUTICALS CO LTDChina1 active DMF
• OLON SPAItaly1 active DMF
• Sichuan Baili Pharmaceutical Co., Ltd.China1 active DMF
• Laurus Labs LimitedIndia1 active DMF
• PLIVA-LACHEMA AS1 active DMF
• JIANGSU HENGRUI PHARMACEUTICALS CO LTDChina1 active DMF
• OLON SPAItaly1 active DMF
• Sichuan Baili Pharmaceutical Co., Ltd.China1 active DMF
• Laurus Labs LimitedIndia1 active DMF
• Emcure Pharmaceuticals LimitedIndia1 active DMF
• SHILPA PHARMA LIFESCIENCES LTD1 active DMF
• Qilu Pharmaceutical Co., Ltd.China1 active DMF
• ARCH PHARMALABS LTD1 active DMF
• Dr. Reddy's Laboratories Ltd.India
• MAC CHEM PRODUCTS INDIA PVT LTD
• LIANYUNGANG JARI PHARMACEUTICAL CO LTD
• CHEMWERTH INC
• Cipla USA, Inc.USA
• AVRA LABORATORIES PRIVATE LTD
• FRESENIUS KABI ONCOLOGY LTD

Showing 25 of 29 suppliers — see the full list in the app.

Patent & exclusivity (US)

Per the FDA Orange Book (39 approved US products), the latest listed US patent on Irinotecan expires 14 Oct 2036 and exclusivity 13 Feb 2031. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate

Canonical SMILES

CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7

InChIKey

UWKQSNNFCGGAFS-XIFFEERXSA-N