Irinotecan

Overview

Irinotecan is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL481).

API suppliers (23)

Suppliers of Irinotecan evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

• Sun Pharmaceutical Industries LimitedIndia2 active DMF GMP on record
• Hetero Labs LimitedIndia1 active DMF GMP on record
• PLIVA-LACHEMA AS1 active DMF
• OLON SPAItaly1 active DMF GMP on record
• Sichuan Xieli Pharmaceutical Co LtdChina1 active DMF
• Emcure Pharmaceuticals LimitedIndia1 active DMF GMP on record
• SHILPA PHARMA LIFESCIENCES LTDIndia1 active DMF
• ARCH PHARMALABS LTDIndia1 active DMF
• COHANCE LIFESCIENCES LTDIndia1 active DMF GMP on record
• JIANGSU HENGRUI PHARMACEUTICALS CO LTDChina1 active DMF GMP on record
• Laurus Labs LimitedIndia1 active DMF GMP on record
• Qilu Pharmaceutical Co., Ltd.China1 active DMF GMP on record
• LIANYUNGANG JARI PHARMACEUTICAL CO LTD
• CHEMWERTH INCFrance
• Cipla USA, Inc.USA
• FRESENIUS KABI ONCOLOGY LTDIndia GMP on record
• POLYMED THERAPEUTICS INC
• AVRA LABORATORIES PRIVATE LTD
• SAI PHYTOCEUTICALS PVT LTD
• MAC CHEM PRODUCTS INDIA PVT LTD GMP on record
• DR REDDYS LABORATORIES LTD GMP on record
• Zhejiang Hisun Pharmaceutical Co., Ltd.China GMP on record
• Cadila Healthcare LimitedIndia

Patent & exclusivity (US)

Per the FDA Orange Book (39 approved US products), the latest listed US patent on Irinotecan expires 15 Oct 2036 and exclusivity 13 Feb 2031. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate

Canonical SMILES

CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7

InChIKey

UWKQSNNFCGGAFS-XIFFEERXSA-N