Fostamatinib

Overview

Fostamatinib is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL2103830).

Patent & exclusivity (US)

Per the FDA Orange Book (4 approved US products), the latest listed US patent on Fostamatinib expires 27 Jul 2032. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

[6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-3-oxopyrido[3,2-b][1,4]oxazin-4-yl]methyl dihydrogen phosphate

Canonical SMILES

CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)(O)O)C

InChIKey

GKDRMWXFWHEQQT-UHFFFAOYSA-N