Fosaprepitant Dimeglumine

Overview

Fosaprepitant Dimeglumine is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL1201782).

API suppliers (5)

Suppliers of Fosaprepitant Dimeglumine backed by a verifiable FDA Type II Drug Master File. Source: FDA quarterly DMF list.

• Ono Pharmaceutical Co., Ltd.Japan2 active DMF
• SCINOPHARM TAIWAN LTD1 active DMF
• APITORIA PHARMA PRIVATE LTDIndia1 active DMF
• Dr. Reddy's Laboratories Ltd.India1 active DMF
• Hetero Drugs LimitedIndia1 active DMF

Patent & exclusivity (US)

Per the FDA Orange Book (12 approved US products), the latest listed US patent on Fosaprepitant Dimeglumine expires 11 Jan 2039. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-2-phosphonato-1H-1,2,4-triazol-3-one;bis(methyl-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]azanium)

Canonical SMILES

C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](N(CCO2)CC3=NC(=O)N(N3)P(=O)([O-])[O-])C4=CC=C(C=C4)F.C[NH2+]C[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O.C[NH2+]C[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O

InChIKey

VRQHBYGYXDWZDL-OOZCZQCLSA-N