Fosaprepitant Dimeglumine

Overview

Fosaprepitant Dimeglumine is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL1201782).

API suppliers (14)

Suppliers of Fosaprepitant Dimeglumine evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

• SCINOPHARM TAIWAN LTDTaiwan1 active DMF
• Hetero Drugs LimitedIndia1 active DMF GMP on record
• ALIVUS LIFE SCIENCES LTDIndia1 active DMF GMP on record
• WOCKHARDT BIO AGFrance1 active DMF
• APITORIA PHARMA PRIVATE LTDIndia1 active DMF GMP on record
• Piramal Pharma LimitedIndia1 active DMF GMP on record
• NAVINTA LLCUnited States1 active DMF
• Viwit Pharmaceutical Co., Ltd.China1 active DMF
• Wisdom Pharmaceutical Co., LtdChina1 active DMF
• GLAND PHARMA LTDIndia1 active DMF GMP on record
• MAHI DRUGS PRIVATE LIMITEDIndia1 active DMF
• Shandong New Time Pharmaceutical Co Ltd1 active DMF GMP on record
• BIOPHORE INDIA PHARMACEUTICALS PVT LTD1 active DMF
• DR REDDYS LABORATORIES LTD1 active DMF GMP on record

Patent & exclusivity (US)

Per the FDA Orange Book (13 approved US products), the latest listed US patent on Fosaprepitant Dimeglumine expires 11 Jan 2039. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-2-phosphonato-1H-1,2,4-triazol-3-one;bis(methyl-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]azanium)

Canonical SMILES

C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](N(CCO2)CC3=NC(=O)N(N3)P(=O)([O-])[O-])C4=CC=C(C=C4)F.C[NH2+]C[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O.C[NH2+]C[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O

InChIKey

VRQHBYGYXDWZDL-OOZCZQCLSA-N