Entrectinib

Overview

Entrectinib is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL1983268).

Patent & exclusivity (US)

Per the FDA Orange Book (3 approved US products), the latest listed US patent on Entrectinib expires 17 Jul 2038 and exclusivity 19 Oct 2030. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-2-(oxan-4-ylamino)benzamide

Canonical SMILES

CN1CCN(CC1)C2=CC(=C(C=C2)C(=O)NC3=NNC4=C3C=C(C=C4)CC5=CC(=CC(=C5)F)F)NC6CCOCC6

InChIKey

HAYYBYPASCDWEQ-UHFFFAOYSA-N