Ensartinib

Overview

Ensartinib is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL4113131).

Patent & exclusivity (US)

Per the FDA Orange Book (2 approved US products), the latest listed US patent on Ensartinib expires 1 Jun 2037 and exclusivity 18 Dec 2029. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-[4-[(3R,5S)-3,5-dimethylpiperazine-1-carbonyl]phenyl]pyridazine-3-carboxamide

Canonical SMILES

C[C@@H]1CN(C[C@@H](N1)C)C(=O)C2=CC=C(C=C2)NC(=O)C3=NN=C(C(=C3)O[C@H](C)C4=C(C=CC(=C4Cl)F)Cl)N

InChIKey

GLYMPHUVMRFTFV-QLFBSQMISA-N