Encorafenib

Overview

Encorafenib is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL3301612).

API suppliers (3)

Suppliers of Encorafenib backed by a verifiable FDA Type II Drug Master File. Source: FDA quarterly DMF list.

• MSN Laboratories Private LimitedIndia1 active DMF
• APITORIA PHARMA PRIVATE LTDIndia1 active DMF
• VALARY LAB PRIVATE LIMITEDIndia1 active DMF

Patent & exclusivity (US)

Per the FDA Orange Book (1 approved US product), the latest listed US patent on Encorafenib expires 5 Aug 2033 and exclusivity 11 Oct 2030. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

methyl N-[(2S)-1-[[4-[3-[5-chloro-2-fluoro-3-(methanesulfonamido)phenyl]-1-propan-2-ylpyrazol-4-yl]pyrimidin-2-yl]amino]propan-2-yl]carbamate

Canonical SMILES

C[C@@H](CNC1=NC=CC(=N1)C2=CN(N=C2C3=C(C(=CC(=C3)Cl)NS(=O)(=O)C)F)C(C)C)NC(=O)OC

InChIKey

CMJCXYNUCSMDBY-ZDUSSCGKSA-N