Edoxaban

Overview

Edoxaban is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL1269025).

API suppliers (17)

Suppliers of Edoxaban evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

• MSN LIFE SCIENCES PRIVATE LIMITEDIndia1 active DMF GMP on record
• HONOUR LAB LTDIndia1 active DMF GMP on record
• Zydus Lifesciences LimitedIndia1 active DMF GMP on record
• Shanghai Desano Chemical Pharmaceutical Co., LtdChina1 active DMF
• METROCHEM API PRIVATE LTDIndia1 active DMF
• AMI LIFESCIENCES PRIVATE LTDIndia1 active DMF GMP on record
• Zhejiang Huahai Pharmaceutical Co., Ltd.China1 active DMF GMP on record
• HIKAL LTDPakistan1 active DMF
• AMOLI ORGANICS (A DIVISION OF UMEDICA LABORATORIES PVT LTD)India1 active DMF
• SAPTAGIR LABORATORIES PRIVATE LTDIndia1 active DMF
• MEGAFINE PHARMA P LTDIndia1 active DMF
• OPTIMUS DRUGS PRIVATE LTDIndia1 active DMF
• Viyash Scientific LtdIndia1 active DMF GMP on record
• Piramal Pharma LimitedIndia1 active DMF GMP on record
• Biocon LimitedIndia1 active DMF
• Neuland Laboratories LimitedIndia1 active DMF
• DR REDDYS LABORATORIES LTD1 active DMF GMP on record

Patent & exclusivity (US)

Per the FDA Orange Book (3 approved US products), the latest listed US patent on Edoxaban expires 28 Mar 2028 and exclusivity 18 Oct 2026. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

N'-(5-chloro-2-pyridinyl)-N-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-[(5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexyl]oxamide

Canonical SMILES

CN1CCC2=C(C1)SC(=N2)C(=O)N[C@@H]3C[C@H](CC[C@@H]3NC(=O)C(=O)NC4=NC=C(C=C4)Cl)C(=O)N(C)C

InChIKey

HGVDHZBSSITLCT-JLJPHGGASA-N