Difelikefalin

Overview

Difelikefalin is a protein active pharmaceutical ingredient (ChEMBL CHEMBL3989915).

API suppliers (1)

Suppliers of Difelikefalin backed by a verifiable FDA Type II Drug Master File. Source: FDA quarterly DMF list.

• Hanmi Pharmaceutical Co., Ltd.South Korea1 active DMF

Patent & exclusivity (US)

Per the FDA Orange Book (1 approved US product), the latest listed US patent on Difelikefalin expires 12 Nov 2032 and exclusivity 23 Aug 2026. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

4-amino-1-[(2R)-6-amino-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid

Canonical SMILES

CC(C)C[C@H](C(=O)N[C@H](CCCCN)C(=O)N1CCC(CC1)(C(=O)O)N)NC(=O)[C@@H](CC2=CC=CC=C2)NC(=O)[C@@H](CC3=CC=CC=C3)N

InChIKey

FWMNVWWHGCHHJJ-SKKKGAJSSA-N