Difelikefalin

Overview

Difelikefalin is a protein active pharmaceutical ingredient (ChEMBL CHEMBL3989915).

API suppliers (1)

Suppliers of Difelikefalin evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

• Hybio Pharmaceutical Co., Ltd.China1 active DMF

Patent & exclusivity (US)

Per the FDA Orange Book (1 approved US product), the latest listed US patent on Difelikefalin expires 12 Nov 2032 and exclusivity 23 Aug 2026. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

4-amino-1-[(2R)-6-amino-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid

Canonical SMILES

CC(C)C[C@H](C(=O)N[C@H](CCCCN)C(=O)N1CCC(CC1)(C(=O)O)N)NC(=O)[C@@H](CC2=CC=CC=C2)NC(=O)[C@@H](CC3=CC=CC=C3)N

InChIKey

FWMNVWWHGCHHJJ-SKKKGAJSSA-N