Dexamethasone

Overview

Dexamethasone is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL384467).

API suppliers (20)

Suppliers of Dexamethasone backed by a verifiable FDA Type II Drug Master File. Source: FDA quarterly DMF list.

• EUROAPI FRANCEFrance3 active DMF
• PHARMACIA AND UPJOHN CO WHOLLY OWNED SUB PFIZER INC3 active DMF
• SYMBIOTEC PHARMALAB PRIVATE LTD2 active DMF
• FARMABIOS SPA2 active DMF
• Zhejiang Hisun Pharmaceutical Co., Ltd.China2 active DMF
• XIAN GUOKANG RUIJIN PHARMACEUTICAL CO LTD2 active DMF
• MAHIMA LIFE SCIENCES PRIVATE LTD1 active DMF
• MAHIMA LIFE SCIENCES PRIVATE LTD1 active DMF
• SYMBIOTICA SPECIALITY INGREDIENTS SDN BHDMalaysia1 active DMF
• COMPANIA ESPANOLA DE SINTESIS QUIMICA SA
• SOCIETA ITALIANA CORTICOSTEROIDI SPA
• QUATRUM
• DIOSYNTH BV
• ROUSSEL CORP
• HOECHST MARION ROUSSEL SA
• CYCLO PRODUCTS INC
• BLASCHIM SPA
• Organon & Co.United States
• SF DURST AND CO INC
• ANTIBIOTICOS SPA

Patent & exclusivity (US)

Per the FDA Orange Book (76 approved US products), the latest listed US patent on Dexamethasone expires 25 Apr 2041 and exclusivity 6 Apr 2028. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

Canonical SMILES

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C

InChIKey

UREBDLICKHMUKA-CXSFZGCWSA-N