Dexamethasone

Overview

Dexamethasone is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL384467).

API suppliers (19)

Suppliers of Dexamethasone evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

• PHARMACIA AND UPJOHN CO LLC WHOLLY OWNED SUB OF PFIZER INC3 active DMF
• EUROAPI FRANCEFrance2 active DMF GMP on record
• FARMABIOS SPAItaly2 active DMF
• SYMBIOTEC PHARMALAB PRIVATE LTDIndia2 active DMF GMP on record
• MAHIMA LIFE SCIENCES PRIVATE LTDIndia1 active DMF
• TIANJIN TIANYAO PHARMACEUTICALS CO LTDChina1 active DMF
• XIAN GUOKANG RUIJIN PHARMACEUTICAL CO LTD1 active DMF
• SHANDONG SIRUI PHARMACEUTICAL CO LTD1 active DMF
• ZHEJIANG XIANJU PHARMACEUTICAL CO LTD1 active DMF
• Organon & Co.United States GMP on record
• SOCIETA ITALIANA CORTICOSTEROIDI SPA
• COMPANIA ESPANOLA DE SINTESIS QUIMICA SA
• DIOSYNTH BV
• HOECHST MARION ROUSSEL SA
• ANTIBIOTICOS SPA
• SF DURST AND CO INC
• ROUSSEL CORP
• BLASCHIM SPA
• CYCLO PRODUCTS INC

Patent & exclusivity (US)

Per the FDA Orange Book (76 approved US products), the latest listed US patent on Dexamethasone expires 26 Apr 2041 and exclusivity 7 Apr 2028. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

Canonical SMILES

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C

InChIKey

UREBDLICKHMUKA-CXSFZGCWSA-N