Degarelix

Overview

Degarelix is a protein active pharmaceutical ingredient (ChEMBL CHEMBL415606).

API suppliers (5)

Suppliers of Degarelix evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

• Hybio Pharmaceutical Co., Ltd.China2 active DMF
• AURO PEPTIDES LTD1 active DMF
• LIANYUNGANG RUNZHONG PHARMACEUTICAL CO LTDChina1 active DMF
• Jiangsu Hansoh Pharmaceutical Group Company LimitedChina1 active DMF GMP on record
• APICORE US LLCUnited States

Patent & exclusivity (US)

Per the FDA Orange Book (2 approved US products), the latest listed US patent on Degarelix expires 27 Apr 2032. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

(4S)-N-[4-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-[[(2R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-6-(propan-2-ylamino)hexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[4-(carbamoylamino)phenyl]-1-oxopropan-2-yl]amino]-3-oxopropyl]phenyl]-2,6-dioxo-1,3-diazinane-4-carboxamide

Canonical SMILES

C[C@H](C(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC2=CC=C(C=C2)NC(=O)N)NC(=O)[C@H](CC3=CC=C(C=C3)NC(=O)[C@@H]4CC(=O)NC(=O)N4)NC(=O)[C@H](CO)NC(=O)[C@@H](CC5=CN=CC=C5)NC(=O)[C@@H](CC6=CC=C(C=C6)Cl)NC(=O)[C@@H](CC7=CC8=CC=CC=C8C=C7)NC(=O)C

InChIKey

MEUCPCLKGZSHTA-XYAYPHGZSA-N