Degarelix

Overview

Degarelix is a protein active pharmaceutical ingredient (ChEMBL CHEMBL415606).

API suppliers (3)

Suppliers of Degarelix backed by a verifiable FDA Type II Drug Master File. Source: FDA quarterly DMF list.

• Hanmi Pharmaceutical Co., Ltd.South Korea2 active DMF
• AURO PEPTIDES LTD1 active DMF
• APICORE US LLCUnited States

Patent & exclusivity (US)

Per the FDA Orange Book (2 approved US products), the latest listed US patent on Degarelix expires 26 Apr 2032. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

(4S)-N-[4-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-[[(2R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2R)-1-amino-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-6-(propan-2-ylamino)hexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[4-(carbamoylamino)phenyl]-1-oxopropan-2-yl]amino]-3-oxopropyl]phenyl]-2,6-dioxo-1,3-diazinane-4-carboxamide

Canonical SMILES

C[C@H](C(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC2=CC=C(C=C2)NC(=O)N)NC(=O)[C@H](CC3=CC=C(C=C3)NC(=O)[C@@H]4CC(=O)NC(=O)N4)NC(=O)[C@H](CO)NC(=O)[C@@H](CC5=CN=CC=C5)NC(=O)[C@@H](CC6=CC=C(C=C6)Cl)NC(=O)[C@@H](CC7=CC8=CC=CC=C8C=C7)NC(=O)C

InChIKey

MEUCPCLKGZSHTA-XYAYPHGZSA-N