Daptomycin

Overview

Daptomycin is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL387675).

API suppliers (3)

Suppliers of Daptomycin backed by a verifiable FDA Type II Drug Master File. Source: FDA quarterly DMF list.

• CHENGDU YACHT BIO-TECHNOLOGY CO LTD2 active DMF
• OLON SPAItaly1 active DMF
• Zhejiang Hisun Pharmaceutical Co., Ltd.China

Patent & exclusivity (US)

Per the FDA Orange Book (32 approved US products), the latest listed US patent on Daptomycin expires 9 Jan 2043. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

(3S)-3-[[(2S)-4-amino-2-[[(2S)-2-(decanoylamino)-3-(1H-indol-3-yl)propanoyl]amino]-4-oxobutanoyl]amino]-4-[[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonazacyclohentriacont-30-yl]amino]-4-oxobutanoic acid

Canonical SMILES

CCCCCCCCCC(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H]3[C@H](OC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC3=O)CCCN)CC(=O)O)C)CC(=O)O)CO)[C@H](C)CC(=O)O)CC(=O)C4=CC=CC=C4N)C

InChIKey

DOAKLVKFURWEDJ-RWDRXURGSA-N