Dacomitinib

Overview

Dacomitinib is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL2105719).

API suppliers (2)

Suppliers of Dacomitinib backed by a verifiable FDA Type II Drug Master File. Source: FDA quarterly DMF list.

• CHONGQING CARELIFE PHARMACEUTICAL CO LTDChina1 active DMF
• MSN Laboratories Private LimitedIndia1 active DMF

Patent & exclusivity (US)

Per the FDA Orange Book (3 approved US products), the latest listed US patent on Dacomitinib expires 27 Sept 2032. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

(E)-N-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide;hydrate

Canonical SMILES

COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)NC(=O)/C=C/CN4CCCCC4.O

InChIKey

BSPLGGCPNTZPIH-IPZCTEOASA-N