Cyclosporine

Overview

Cyclosporine is a protein active pharmaceutical ingredient (ChEMBL CHEMBL160).

API suppliers (11)

Suppliers of Cyclosporine evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

• TAPI NL BVNetherlands2 active DMF
• NORTH CHINA PHARMACEUTICAL HUASHENG CO LTDChina1 active DMF GMP on record
• FISHFA BIOGENICS (A DIV OF FISHFA RUBBERS LTD)India1 active DMF
• CONCORD BIOTECH LTDIndia1 active DMF GMP on record
• ZHEJIANG RUIBANG LABORATORIES INCChina1 active DMF
• Apotex Inc.Canada1 active DMF
• CURIA ITALY SRLItaly1 active DMF GMP on record
• FUJIAN KERUI PHARMACEUTICAL CO LTDChina1 active DMF
• Abbvie Inc.United States1 active DMF GMP on record
• GALENA AS
• WATSON LABORATORIES INC

Patent & exclusivity (US)

Per the FDA Orange Book (41 approved US products), the latest listed US patent on Cyclosporine expires 1 Apr 2042 and exclusivity 23 Jun 2028. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone

Canonical SMILES

CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C

InChIKey

PMATZTZNYRCHOR-CGLBZJNRSA-N