Cyclosporine

Overview

Cyclosporine is a protein active pharmaceutical ingredient (ChEMBL CHEMBL160).

API suppliers (16)

Suppliers of Cyclosporine backed by a verifiable FDA Type II Drug Master File. Source: FDA quarterly DMF list.

• TAPI NL BV2 active DMF
• CURIA ITALY SRL1 active DMF
• Apotex Inc.Canada1 active DMF
• ZHEJIANG RUIBANG LABORATORIES INCChina1 active DMF
• Abbvie Inc.United States1 active DMF
• FUJIAN KERUI PHARMACEUTICAL CO LTDChina1 active DMF
• CURIA ITALY SRL1 active DMF
• CURIA ITALY SRL1 active DMF
• CONCORD BIOTECH LTD1 active DMF
• FUJIAN KERUI PHARMACEUTICAL CO LTDChina1 active DMF
• Abbvie Inc.United States1 active DMF
• ZHEJIANG RUIBANG LABORATORIES INCChina1 active DMF
• Apotex Inc.Canada1 active DMF
• CONCORD BIOTECH LTD1 active DMF
• GALENA AS
• WATSON LABORATORIES INC

Patent & exclusivity (US)

Per the FDA Orange Book (41 approved US products), the latest listed US patent on Cyclosporine expires 31 Mar 2042 and exclusivity 22 Jun 2028. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone

Canonical SMILES

CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C

InChIKey

PMATZTZNYRCHOR-CGLBZJNRSA-N