Colchicine

Overview

Colchicine is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL107).

API suppliers (13)

Suppliers of Colchicine evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

• DR WILLMAR SCHWABE INDIA PVT LTDIndia1 active DMF
• ALKALOIDS BIOACTIVES PRIVATE LTDIndia1 active DMF
• PH HEALTH LTD1 active DMF
• INDENA SPAItaly1 active DMF GMP on record
• CHEMPLAST SANMAR LTDIndia1 active DMF
• SOLARA ACTIVE PHARMA SCIENCES LTDIndia1 active DMF GMP on record
• CHEMICAL RESOURCES (CHERESO)India1 active DMF
• ALCHEM INTERNATIONAL LTDUnited States GMP on record
• SARV BIO LABS PVT LTD
• ROUSSELL UCLAF
• VITAL LABORATORIES PVT LTD
• SM ORGANICS PRIVATE LTD
• ALKALOIDS CORPIndia

Patent & exclusivity (US)

Per the FDA Orange Book (21 approved US products), the latest listed US patent on Colchicine expires 20 Dec 2037. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide

Canonical SMILES

CC(=O)N[C@H]1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC

InChIKey

IAKHMKGGTNLKSZ-INIZCTEOSA-N