Colchicine

Overview

Colchicine is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL107).

API suppliers (14)

Suppliers of Colchicine backed by a verifiable FDA Type II Drug Master File. Source: FDA quarterly DMF list.

• PH HEALTH LTD1 active DMF
• PH HEALTH LTD1 active DMF
• INDENA SPAItaly1 active DMF
• ALKALOIDS BIOACTIVES PRIVATE LTD1 active DMF
• CHEMPLAST SANMAR LTD1 active DMF
• SOLARA ACTIVE PHARMA SCIENCES LTD1 active DMF
• CHEMPLAST SANMAR LTD1 active DMF
• ALKALOIDS BIOACTIVES PRIVATE LTD1 active DMF
• ROUSSELL UCLAF
• SARV BIO LABS PVT LTD
• SM ORGANICS PRIVATE LTD
• VITAL LABORATORIES PVT LTD
• ALCHEM INTERNATIONAL LTD
• ALKALOIDS CORP

Patent & exclusivity (US)

Per the FDA Orange Book (21 approved US products), the latest listed US patent on Colchicine expires 20 Dec 2037. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide

Canonical SMILES

CC(=O)N[C@H]1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC

InChIKey

IAKHMKGGTNLKSZ-INIZCTEOSA-N