Ceftaroline Fosamil

Overview

Ceftaroline Fosamil is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL501122).

Patent & exclusivity (US)

Per the FDA Orange Book (4 approved US products), the latest listed US patent on Ceftaroline Fosamil expires 10 Feb 2031. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

(6R,7R)-7-[[(2Z)-2-ethoxyimino-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetyl]amino]-3-[[4-(1-methylpyridin-1-ium-4-yl)-1,3-thiazol-2-yl]sulfanyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Canonical SMILES

CCO/N=C(/C1=NSC(=N1)NP(=O)(O)O)\C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)SC4=NC(=CS4)C5=CC=[N+](C=C5)C)C(=O)[O-]

InChIKey

ZCCUWMICIWSJIX-NQJJCJBVSA-N