Cefiderocol

Overview

Cefiderocol is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL3989974).

Patent & exclusivity (US)

Per the FDA Orange Book (1 approved US product), the latest listed US patent on Cefiderocol expires 3 Sept 2035 and exclusivity 14 Nov 2029. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(2-carboxypropan-2-yloxyimino)acetyl]amino]-3-[[1-[2-[(2-chloro-3,4-dihydroxybenzoyl)amino]ethyl]pyrrolidin-1-ium-1-yl]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Canonical SMILES

CC(C)(C(=O)O)O/N=C(/C1=CSC(=N1)N)\C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C[N+]4(CCCC4)CCNC(=O)C5=C(C(=C(C=C5)O)O)Cl)C(=O)[O-]

InChIKey

DBPPRLRVDVJOCL-FQRUVTKNSA-N