Caspofungin

Overview

Caspofungin is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL1630575).

API suppliers (5)

Suppliers of Caspofungin backed by a verifiable FDA Type II Drug Master File. Source: FDA quarterly DMF list.

• TAPI NL BV1 active DMF
• TAPI NL BV1 active DMF
• SHANGHAI TECHWELL BIOPHARMACEUTICAL CO LTD
• Taro Pharmaceutical Industries Ltd.Israel
• Lek Pharmaceuticals D.D.Slovenia

Patent & exclusivity (US)

Per the FDA Orange Book (8 approved US products), the latest listed US patent on Caspofungin expires 21 Dec 2032. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

(10R,12S)-N-[(3S,6S,9S,11R,15S,18S,20R,21S,24S,25S)-21-(2-aminoethylamino)-3-[(1R)-3-amino-1-hydroxypropyl]-6-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-11,20,25-trihydroxy-15-[(1R)-1-hydroxyethyl]-2,5,8,14,17,23-hexaoxo-1,4,7,13,16,22-hexazatricyclo[22.3.0.09,13]heptacosan-18-yl]-10,12-dimethyltetradecanamide

Canonical SMILES

CC[C@H](C)C[C@H](C)CCCCCCCCC(=O)N[C@H]1C[C@H]([C@H](NC(=O)[C@@H]2[C@H](CCN2C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@@H](NC1=O)[C@@H](C)O)O)[C@@H]([C@H](C4=CC=C(C=C4)O)O)O)[C@@H](CCN)O)O)NCCN)O

InChIKey

JYIKNQVWKBUSNH-WVDDFWQHSA-N