Caspofungin

Overview

Caspofungin is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL1630575).

API suppliers (2)

Suppliers of Caspofungin evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

• BRIGHTGENE BIO-MEDICAL TECHNOLOGY CO LTDChina1 active DMF
• Teva Pharmaceutical Industries Ltd.Israel GMP on record

Patent & exclusivity (US)

Per the FDA Orange Book (8 approved US products), the latest listed US patent on Caspofungin expires 21 Dec 2032. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

(10R,12S)-N-[(3S,6S,9S,11R,15S,18S,20R,21S,24S,25S)-21-(2-aminoethylamino)-3-[(1R)-3-amino-1-hydroxypropyl]-6-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-11,20,25-trihydroxy-15-[(1R)-1-hydroxyethyl]-2,5,8,14,17,23-hexaoxo-1,4,7,13,16,22-hexazatricyclo[22.3.0.09,13]heptacosan-18-yl]-10,12-dimethyltetradecanamide

Canonical SMILES

CC[C@H](C)C[C@H](C)CCCCCCCCC(=O)N[C@H]1C[C@H]([C@H](NC(=O)[C@@H]2[C@H](CCN2C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@@H](NC1=O)[C@@H](C)O)O)[C@@H]([C@H](C4=CC=C(C=C4)O)O)O)[C@@H](CCN)O)O)NCCN)O

InChIKey

JYIKNQVWKBUSNH-WVDDFWQHSA-N