Carfilzomib

Overview

Carfilzomib is a protein active pharmaceutical ingredient (ChEMBL CHEMBL451887).

API suppliers (16)

Suppliers of Carfilzomib evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

• DR REDDYS LABORATORIES LTD1 active DMF GMP on record
• TONGSHENG PHARMACEUTICAL (JINGMEN) CO LTD1 active DMF
• BIOPHORE INDIA PHARMACEUTICALS PVT LTD1 active DMF
• TAPI NL BVNetherlands1 active DMF
• Laurus Labs LimitedIndia1 active DMF GMP on record
• Intas Pharmaceuticals Ltd.India1 active DMF GMP on record
• Shandong New Time Pharmaceutical Co Ltd1 active DMF GMP on record
• Jiangsu Xidi Pharmaceuticals Co., LtdChina1 active DMF
• Hetero Labs LimitedIndia1 active DMF GMP on record
• Sichuan Huiyu Pharmaceutical Co., Ltd.China1 active DMF GMP on record
• Chongqing Sintaho Pharmaceutical Co., Ltd.China1 active DMF
• CHONGQING MIDECO PHARMACEUTICAL CO LTD1 active DMF
• Wisdom Pharmaceutical Co., LtdChina1 active DMF
• FRESENIUS KABI ONCOLOGY LTDIndia GMP on record
• SEACROSS PHARMA USA INCChina
• CHUNGHWA CHEMICAL SYNTHESIS AND BIOTECH CO LTD GMP on record

Patent & exclusivity (US)

Per the FDA Orange Book (4 approved US products), the latest listed US patent on Carfilzomib expires 29 Oct 2041 and exclusivity 22 Nov 2028. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

(2S)-4-methyl-N-[(2S)-1-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]-4-phenylbutanoyl]amino]pentanamide

Canonical SMILES

CC(C)C[C@@H](C(=O)[C@]1(CO1)C)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC3=CC=CC=C3)NC(=O)CN4CCOCC4

InChIKey

BLMPQMFVWMYDKT-NZTKNTHTSA-N