Cabozantinib S-MALATE

Overview

Cabozantinib S-MALATE is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL2103868).

API suppliers (6)

Suppliers of Cabozantinib S-MALATE evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

• MSN Laboratories Private LimitedIndia1 active DMF GMP on record
• FERMION OYFinland1 active DMF GMP on record
• Natco PharmaIndia1 active DMF GMP on record
• SICHUAN ELIXIR PHARMACEUTICAL CO LTD1 active DMF
• Zhejiang Tianyu Pharmaceutical Co., Ltd.China1 active DMF GMP on record
• Shanghai Huilun Pharmaceutical Co., Ltd.China1 active DMF

Patent & exclusivity (US)

Per the FDA Orange Book (5 approved US products), the latest listed US patent on Cabozantinib S-MALATE expires 9 Jul 2033 and exclusivity 26 Mar 2032. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

1-N-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide;(2S)-2-hydroxybutanedioic acid

Canonical SMILES

COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F.C([C@@H](C(=O)O)O)C(=O)O

InChIKey

HFCFMRYTXDINDK-WNQIDUERSA-N