Cabazitaxel

Overview

Cabazitaxel is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL1201748).

API suppliers (3)

Suppliers of Cabazitaxel backed by a verifiable FDA Type II Drug Master File. Source: FDA quarterly DMF list.

• SHANDONG XINHUA PHARMACEUTICAL CO LTDChina2 active DMF
• Sichuan Baili Pharmaceutical Co., Ltd.China2 active DMF
• PTC Therapeutics, Inc.United States

Patent & exclusivity (US)

Per the FDA Orange Book (3 approved US products), the latest listed US patent on Cabazitaxel expires 26 Apr 2031. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

[(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-acetyloxy-1-hydroxy-15-[(2R,3S)-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]oxy-9,12-dimethoxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate

Canonical SMILES

CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)OC)C)OC

InChIKey

BMQGVNUXMIRLCK-OAGWZNDDSA-N