Cabazitaxel

Overview

Cabazitaxel is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL1201748).

API suppliers (13)

Suppliers of Cabazitaxel evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

• DR REDDYS LABORATORIES LTD1 active DMF GMP on record
• Sichuan Xieli Pharmaceutical Co LtdChina1 active DMF
• Shandong Anhong Pharmaceutical Co., Ltd.China1 active DMF GMP on record
• TAPI NL BVNetherlands1 active DMF
• Hetero Labs LimitedIndia1 active DMF GMP on record
• Laurus Labs LimitedIndia1 active DMF GMP on record
• Tianjin Weijie Pharmaceutical Co., Ltd.China1 active DMF
• SHILPA PHARMA LIFESCIENCES LTDIndia1 active DMF
• INDENA SPAItaly1 active DMF GMP on record
• Shandong New Time Pharmaceutical Co Ltd1 active DMF GMP on record
• SICHUAN ELIXIR PHARMACEUTICAL CO LTD1 active DMF
• Jiangsu Xidi Pharmaceuticals Co., LtdChina1 active DMF
• POLYMED THERAPEUTICS INC

Patent & exclusivity (US)

Per the FDA Orange Book (3 approved US products), the latest listed US patent on Cabazitaxel expires 27 Apr 2031. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

[(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-acetyloxy-1-hydroxy-15-[(2R,3S)-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]oxy-9,12-dimethoxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate

Canonical SMILES

CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)OC)C)OC

InChIKey

BMQGVNUXMIRLCK-OAGWZNDDSA-N