Bumetanide

Overview

Bumetanide is a potent loop diuretic used to treat edema associated with heart failure, liver cirrhosis, and renal disease, including the nephrotic syndrome. It works by inhibiting the sodium-potassium-chloride symporter in the thick ascending limb of the loop of Henle, thereby increasing urine production.

API suppliers (6)

Suppliers of Bumetanide backed by a verifiable FDA Type II Drug Master File. Source: FDA quarterly DMF list.

• OLON SPAItaly1 active DMF
• Ono Pharmaceutical Co., Ltd.Japan1 active DMF
• OLON SPAItaly1 active DMF
• INDUSTRIALE CHIMICA SRLItaly1 active DMF
• INDUSTRIALE CHIMICA SRLItaly1 active DMF
• QUIMICA SINTETICA SASpain

Patent & exclusivity (US)

Per the FDA Orange Book (48 approved US products), the latest listed US patent on Bumetanide expires 13 May 2045. Generic API sourcing typically opens up once these lapse.

Therapeutic areas