Berotralstat

Overview

Berotralstat is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL5189739).

Patent & exclusivity (US)

Per the FDA Orange Book (6 approved US products), the latest listed US patent on Berotralstat expires 1 May 2040 and exclusivity 11 Jun 2029. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

1-[3-(aminomethyl)phenyl]-N-[5-[(R)-(3-cyanophenyl)-(cyclopropylmethylamino)methyl]-2-fluorophenyl]-3-(trifluoromethyl)pyrazole-5-carboxamide

Canonical SMILES

C1CC1CN[C@@H](C2=CC(=C(C=C2)F)NC(=O)C3=CC(=NN3C4=CC=CC(=C4)CN)C(F)(F)F)C5=CC=CC(=C5)C#N

InChIKey

UXNXMBYCBRBRFD-MUUNZHRXSA-N