Avapritinib

Overview

Avapritinib is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL4204794).

Patent & exclusivity (US)

Per the FDA Orange Book (5 approved US products), the latest listed US patent on Avapritinib expires 8 Mar 2042 and exclusivity 22 May 2030. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

(1S)-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine

Canonical SMILES

C[C@](C1=CC=C(C=C1)F)(C2=CN=C(N=C2)N3CCN(CC3)C4=NC=NN5C4=CC(=C5)C6=CN(N=C6)C)N

InChIKey

DWYRIWUZIJHQKQ-SANMLTNESA-N