Aprepitant

Overview

Aprepitant is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL1471).

API suppliers (14)

Suppliers of Aprepitant evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

• MSN PHARMACHEM PRIVATE LTDIndia3 active DMF
• Wisdom Pharmaceutical Co., LtdChina2 active DMF
• ALIVUS LIFE SCIENCES LTDIndia2 active DMF GMP on record
• Piramal Pharma LimitedIndia1 active DMF GMP on record
• JUBILANT BIOSYS LTDIndia1 active DMF
• OLON SPAItaly1 active DMF GMP on record
• Viwit Pharmaceutical Co., Ltd.China1 active DMF
• SOLARA ACTIVE PHARMA SCIENCES LTDIndia1 active DMF GMP on record
• INKE SASpain1 active DMF
• Sichuan Kelun Pharmaceutical Co., Ltd.China1 active DMF
• MAHI DRUGS PRIVATE LIMITEDIndia1 active DMF
• DR REDDYS LABORATORIES LTD1 active DMF GMP on record
• PharmathenGreece1 active DMF
• Hetero Drugs LimitedIndia1 active DMF GMP on record

Patent & exclusivity (US)

Per the FDA Orange Book (15 approved US products), the latest listed US patent on Aprepitant expires 18 Sept 2035. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one

Canonical SMILES

C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](N(CCO2)CC3=NC(=O)NN3)C4=CC=C(C=C4)F

InChIKey

ATALOFNDEOCMKK-OITMNORJSA-N