Aprepitant

13 FDA-DMF suppliersSmall Molecule

Overview

Aprepitant is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL1471).

API suppliers (7)

Suppliers of Aprepitant backed by a verifiable FDA Type II Drug Master File. Source: FDA quarterly DMF list.

  • MSN PHARMACHEM PRIVATE LTD3 active DMF
  • Ono Pharmaceutical Co., Ltd.Japan2 active DMF
  • ALIVUS LIFE SCIENCES LTD2 active DMF
  • Hetero Drugs LimitedIndia1 active DMF
  • Dr. Reddy's Laboratories Ltd.India1 active DMF
  • Dr. Reddy's Laboratories Ltd.India1 active DMF
  • Dr. Reddy's Laboratories Ltd.India1 active DMF

Patent & exclusivity (US)

Per the FDA Orange Book (14 approved US products), the latest listed US patent on Aprepitant expires 17 Sept 2035. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name
5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one
Canonical SMILES
C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](N(CCO2)CC3=NC(=O)NN3)C4=CC=C(C=C4)F
InChIKey
ATALOFNDEOCMKK-OITMNORJSA-N

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