Amikacin

Overview

Amikacin is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL177).

API suppliers (4)

Suppliers of Amikacin evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

• Shandong Anxin Pharmaceutical Co., Ltd.China1 active DMF GMP on record
• PKUCARE CHONGQING DAXIN PHARMACEUTICAL CO LTD
• ZHEJIANG JINHUA CONBA BIO-PHARM CO LTDChina GMP on record
• Chongqing Daxin Pharmaceutical Co., Ltd.China

Patent & exclusivity (US)

Per the FDA Orange Book (8 approved US products), the latest listed US patent on Amikacin expires 15 May 2035 and exclusivity 28 Sept 2030. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

(2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide

Canonical SMILES

C1[C@@H]([C@H]([C@@H]([C@H]([C@@H]1NC(=O)[C@H](CCN)O)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)N)O)O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CN)O)O)O)N

InChIKey

LKCWBDHBTVXHDL-RMDFUYIESA-N