Amikacin

Overview

Amikacin is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL177).

API suppliers (13)

Suppliers of Amikacin backed by a verifiable FDA Type II Drug Master File. Source: FDA quarterly DMF list.

• ACS DOBFAR SPAItaly1 active DMF
• ACS DOBFAR SPAItaly1 active DMF
• ACS DOBFAR SPAItaly1 active DMF
• SHANDONG XINHUA PHARMACEUTICAL CO LTDChina1 active DMF
• SHANDONG XINHUA PHARMACEUTICAL CO LTDChina1 active DMF
• SHANDONG XINHUA PHARMACEUTICAL CO LTDChina1 active DMF
• PKUCARE CHONGQING DAXIN PHARMACEUTICAL CO LTD
• CHEMICAL PHARMACEUTICAL RESEARCH INSTITUTE NIHFI LTD
• GIST-BROCADES NV PHARMACEUTICALS
• Bristol-Myers Squibb CompanyUSA
• Abbott LaboratoriesUSA
• CHONGQING CARELIFE PHARMACEUTICAL CO LTDChina
• ZHEJIANG JINHUA CONBA BIO-PHARM CO LTDChina

Patent & exclusivity (US)

Per the FDA Orange Book (8 approved US products), the latest listed US patent on Amikacin expires 14 May 2035 and exclusivity 27 Sept 2030. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

(2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide

Canonical SMILES

C1[C@@H]([C@H]([C@@H]([C@H]([C@@H]1NC(=O)[C@H](CCN)O)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)N)O)O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CN)O)O)O)N

InChIKey

LKCWBDHBTVXHDL-RMDFUYIESA-N