Resmetirom

Overview

Resmetirom is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL3261331).

API suppliers (12)

Suppliers of Resmetirom evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

• LEE PHARMA LTDIndia1 active DMF GMP on record
• LEWENS LABS PRIVATE LTDIndia1 active DMF
• SICHUAN ELIXIR PHARMACEUTICAL CO LTD1 active DMF
• Cipla USA, Inc.USA1 active DMF
• Zhejiang Hisun Pharmaceutical Co., Ltd.China1 active DMF GMP on record
• CHANGZHOU PHARMACEUTICAL FACTORYChina1 active DMF GMP on record
• METROCHEM API PRIVATE LTDIndia1 active DMF
• APICHEM Laboratories Private LimitedIndia1 active DMF
• BIOPHORE INDIA PHARMACEUTICALS PVT LTD1 active DMF
• Shandong Loncom Pharmaceutical Co.,ltd.China1 active DMF
• AMI LIFESCIENCES PRIVATE LTDIndia1 active DMF GMP on record
• Zydus Lifesciences LimitedIndia1 active DMF GMP on record

Patent & exclusivity (US)

Per the FDA Orange Book (3 approved US products), the latest listed US patent on Resmetirom expires 4 Feb 2045 and exclusivity 14 Mar 2029. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

2-[3,5-dichloro-4-[(6-oxo-5-propan-2-yl-1H-pyridazin-3-yl)oxy]phenyl]-3,5-dioxo-1,2,4-triazine-6-carbonitrile

Canonical SMILES

CC(C)C1=CC(=NNC1=O)OC2=C(C=C(C=C2Cl)N3C(=O)NC(=O)C(=N3)C#N)Cl

InChIKey

FDBYIYFVSAHJLY-UHFFFAOYSA-N