Naltrexone

CAS 16590-41-3 8 FDA-DMF suppliersSmall Molecule

Overview

Naltrexone is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL19019).

API suppliers (5)

Suppliers of Naltrexone backed by a verifiable FDA Type II Drug Master File. Source: FDA quarterly DMF list.

  • Sun Pharmaceutical Industries LimitedIndia2 active DMF
  • SANECA PHARMACEUTICALS AS1 active DMF
  • NORAMCO INC1 active DMF
  • DIOSYNTH BV
  • Organon & Co.United States

Patent & exclusivity (US)

Per the FDA Orange Book (9 approved US products), the latest listed US patent on Naltrexone expires 14 Oct 2029. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name
(4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
Canonical SMILES
C1CC1CN2CC[C@]34[C@@H]5C(=O)CC[C@]3([C@H]2CC6=C4C(=C(C=C6)O)O5)O
InChIKey
DQCKKXVULJGBQN-XFWGSAIBSA-N

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