Liraglutide

Overview

Liraglutide is a protein active pharmaceutical ingredient (ChEMBL CHEMBL4084119).

API suppliers (20)

Suppliers of Liraglutide backed by a verifiable FDA Type II Drug Master File. Source: FDA quarterly DMF list.

• Pharmaron Beijing Co., Ltd.China1 active DMF
• BACHEM AMERICAS INC1 active DMF
• SHENZHEN JYMED TECHNOLOGY CO LTDChina1 active DMF
• Dr. Reddy's Laboratories Ltd.India1 active DMF
• FRESENIUS KABI IPSUM SRLItaly1 active DMF
• HANGZHOU JIUYUAN GENE ENGINEERING CO LTDChina1 active DMF
• POLYPEPTIDE LABORATORIES INCUnited States1 active DMF
• Biocon LimitedIndia1 active DMF
• ZHEJIANG PEPTITES BIOTECH CO LTDChina1 active DMF
• Sun Pharmaceutical Industries LimitedIndia1 active DMF
• SCINOPHARM TAIWAN LTDTaiwan1 active DMF
• AURO PEPTIDES LTD1 active DMF
• SHANDONG CHENZHONG BIOPHARMACEUTICAL CO LTDChina1 active DMF
• ASYMCHEM LIFE SCIENCE TIANJIN CO LTDChina1 active DMF
• SHILPA PHARMA LIFESCIENCES LTDIndia1 active DMF
• SUZHOU TIANMA PHARMA GROUP TIANJI BIO-PHARMACEUTICAL CO LTDChina1 active DMF
• Piramal Pharma LimitedIndia1 active DMF
• SINOPEP-ALLSINO BIOPHARMACEUTICAL CO LTDChina1 active DMF
• CHENGDU SHENGNUO BIOPHARM CO LTDChina1 active DMF
• Amphastar Pharmaceuticals, Inc.United States

Patent & exclusivity (US)

Per the FDA Orange Book (13 approved US products), the latest listed US patent on Liraglutide expires 9 Jul 2037 and exclusivity 24 Feb 2026. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

(2S)-5-[[(5S)-5-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]propanoyl]amino]-4-carboxybutanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-4-carboxybutanoyl]amino]acetyl]amino]-5-oxopentanoyl]amino]propanoyl]amino]propanoyl]amino]-6-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-carbamimidamido-1-[[2-[[(2S)-5-carbamimidamido-1-(carboxymethylamino)-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-6-oxohexyl]amino]-2-(hexadecanoylamino)-5-oxopentanoic acid

Canonical SMILES

CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCCC[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC2=CNC3=CC=CC=C32)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)N)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC5=CC=CC=C5)NC(=O)[C@H]([C@@H](C)O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CC6=CN=CN6)N)C(=O)O

InChIKey

YSDQQAXHVYUZIW-QCIJIYAXSA-N