Lapatinib Ditosylate

Overview

Lapatinib Ditosylate is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL1201179).

API suppliers (3)

Suppliers of Lapatinib Ditosylate backed by a verifiable FDA Type II Drug Master File. Source: FDA quarterly DMF list.

• Pharmaron Beijing Co., Ltd.China1 active DMF
• Forest Laboratories, Inc.United States1 active DMF
• Granules India LimitedIndia

Patent & exclusivity (US)

Per the FDA Orange Book (3 approved US products), the latest listed US patent on Lapatinib Ditosylate expires 17 Sept 2029. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine;bis(4-methylbenzenesulfonic acid);hydrate

Canonical SMILES

CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O.CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl.O

InChIKey

XNRVGTHNYCNCFF-UHFFFAOYSA-N