Dihydroergotamine

Overview

Dihydroergotamine is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL1732).

API suppliers (2)

Suppliers of Dihydroergotamine backed by a verifiable FDA Type II Drug Master File. Source: FDA quarterly DMF list.

• CURIA ITALY SRL1 active DMF
• CURIA ITALY SRL1 active DMF

Patent & exclusivity (US)

Per the FDA Orange Book (13 approved US products), the latest listed US patent on Dihydroergotamine expires 11 Oct 2041 and exclusivity 29 Apr 2028. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

(6aR,9R,10aR)-N-[(1S,2S,4R,7S)-7-benzyl-2-hydroxy-4-methyl-5,8-dioxo-3-oxa-6,9-diazatricyclo[7.3.0.02,6]dodecan-4-yl]-7-methyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide

Canonical SMILES

C[C@@]1(C(=O)N2[C@H](C(=O)N3CCC[C@H]3[C@@]2(O1)O)CC4=CC=CC=C4)NC(=O)[C@@H]5C[C@H]6[C@@H](CC7=CNC8=CC=CC6=C78)N(C5)C

InChIKey

LUZRJRNZXALNLM-JGRZULCMSA-N