Dihydroergotamine

Overview

Dihydroergotamine is a small molecule active pharmaceutical ingredient (ChEMBL CHEMBL1732).

API suppliers (1)

Suppliers of Dihydroergotamine evidenced by a US FDA Type II Drug Master File or an EU Certificate of Suitability (CEP). Sources: FDA DMF list, EDQM certification database.

• CURIA ITALY SRLItaly1 active DMF GMP on record

Patent & exclusivity (US)

Per the FDA Orange Book (13 approved US products), the latest listed US patent on Dihydroergotamine expires 12 Oct 2041 and exclusivity 30 Apr 2028. Generic API sourcing typically opens up once these lapse.

Chemical identity

IUPAC name

(6aR,9R,10aR)-N-[(1S,2S,4R,7S)-7-benzyl-2-hydroxy-4-methyl-5,8-dioxo-3-oxa-6,9-diazatricyclo[7.3.0.02,6]dodecan-4-yl]-7-methyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide

Canonical SMILES

C[C@@]1(C(=O)N2[C@H](C(=O)N3CCC[C@H]3[C@@]2(O1)O)CC4=CC=CC=C4)NC(=O)[C@@H]5C[C@H]6[C@@H](CC7=CNC8=CC=CC6=C78)N(C5)C

InChIKey

LUZRJRNZXALNLM-JGRZULCMSA-N